Year : 2013 | Volume
: 6 | Issue : 1 | Page : 31--38
Effect of yoga exercise therapy on oxidative stress indicators with end-stage renal disease on hemodialysis
Lorenzo Gordon1, Donovan A McGrowder2, Yeiny T Pena3, Elsa Cabrera4, Marilyn B Lawrence-Wright5
1 Kingston Public Hospital, North Street, Jamaica
2 Department of Pathology, Faculty of Medical Sciences, University of the West Indies, Mona, Jamaica
3 Department of Medicine, May Pen Hospital, Clarendon, Jamaica
4 Hermanos Ameijeiras Hospital, Havana, Cuba
5 Department of Medicine, University of the West Indies, Mona, Kingston 7, Jamaica
Background: Oxidative stress promotes endothelial dysfunction and atherosclerosis in chronic renal disease.
Objectives: This study investigated the impact of Hatha yoga on oxidative stress indicators and oxidant status, in patients with end-stage renal disease (ESRD) on hemodialysis.
Design: This prospective randomized study consisted of 33 ESRD patients in the Hatha yoga exercise group who were matched with 35 ESRD patients in the control group.
Outcome Measures: The oxidative stress indicators (malondialdehyde - MDA, protein oxidation - POX, phospholipase A2 - PLA2 activity) and the oxidative status (superoxide dismutase (SOD) and catalase activities) were determined in the blood samples taken at the pre-hemodialysis treatment, at baseline (0 months) and after four months.
Results: In patients in the Hatha yoga exercise group, lipid peroxidation, as indicated by MDA decreased by 4.0% after four months (P = 0.096). There was also a significant reduction in the activity of PLA from 2.68 ± 0.02 IU / L to 2.34 IU / L (− 12.7%; P = 0.010) and POX from 2.28 ± 0.02 nmol / mg to 2.22 ± 0.01 nmol / mg (− 22.6%; P = 0.0001). The activity of SOD significantly increased from 12.91 ± 0.17 U / L to 13.54 ± 0.15 U / L (4.65%; P = 0.0001) and catalase from 79.83 ± 0.63 U / L to 80.54 ± 0.80 U / L (0.90%; P = 0.0001). There was a significant correlation between the pre-hemodialysis oxidative stress parameters at the zero month and after four months for the activities of PLA (r = 0.440), catalase (r = 0.872), and SOD (r = 0.775).
Conclusions: These findings suggest that the Hatha yoga exercise has therapeutic, preventative, and protective effects in ESRD subjects, by decreasing oxidative stress.
Department of Medicine, Kingston Public Hospital, North Street, Kingston
|How to cite this article:|
Gordon L, McGrowder DA, Pena YT, Cabrera E, Lawrence-Wright MB. Effect of yoga exercise therapy on oxidative stress indicators with end-stage renal disease on hemodialysis.Int J Yoga 2013;6:31-38
|How to cite this URL:|
Gordon L, McGrowder DA, Pena YT, Cabrera E, Lawrence-Wright MB. Effect of yoga exercise therapy on oxidative stress indicators with end-stage renal disease on hemodialysis. Int J Yoga [serial online] 2013 [cited 2020 Sep 23 ];6:31-38
Available from: http://www.ijoy.org.in/article.asp?issn=0973-6131;year=2013;volume=6;issue=1;spage=31;epage=38;aulast=Gordon;type=0